The10th Annual Meeting
of the Israel Analytical Chemistry Society
Conference & Exhibition
January 23-24, 2007





Dear Colleagues

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Scientific Program
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Gallery of ISRANALYTICA 2007
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Scientific Program

January 23, 2007

07:30 - 09:00
09:00 – 09:10
Opening Remarks
09:10 – 10:00
Chair: Eli Grushka
The Limits of Efficiency in Liquid Chromatography
John G. Dorsey

Florida State University, Florida, USA

10:00 – 10:40
Coffee Break, Posters & Vendor Exhibits
Hall A
Hall B
Hall C

Session A
10:40 – 12:20

Chair: Igal Gozlan

Session B

10:40 – 12:20
Chair: Michael Gaft

Supported by the Grand Water Research Institute
Session C
10:40 – 12:20
Chair: Isaac (Joe) Brenner

10:40 – 11:00

The Use of Pluronic Block Copolymer to Manipulate Selectivities of Small Molecules in Capillary Electrophoresis
Eli Grushka
The Hebrew University, Jerusalem

Application of Cavity Ringdown to Detection of Laser Induced Aerosols
Valery Bulatov
Technion- Israel Institute
of Technology, Haifa

The Proposed Chemical Regulations of Drinking Water in Israel: General Trends and Analytical Aspects
Ovadia Lev
The Hebrew University, Jerusalem

11:00 – 11:20

Sub-2 μM Particles in Liquid Chromatography: Speeding up Separations and/or Boosting Chromatographic Performance
Shulamit Levin
Medtechnica, Petach Tikva

Fluorescence Kinetics in the Aid for DNA Mutations Analysis
Dani Bercovich

Migal, Kiryat-Shmona

Determination of Diethylen Glycole in Marine Water by Nano-FIA-Direct EI-MS Pierangela Palma
University of Urbino, Urbino, Italy

11:20 – 11:40

Oleyl Alcohol: Purity Testing by Reverse Phase HPLC with Evaporative Light Scattering Detection
Vladimir Ioffe

Teva Pharmaceutical Industries, Netanya

Parchment Characterization by Complex Analytical Method
Bella Dolgin
Technion- Israel Institute of Technology, Haifa

Cyanobacteria Toxins in Lake Kinneret – from Initial Identification to a Recent Revision of Drinking Water Standards
Assaf Sukenik
Yigal Allon Kinneret Limnological Laboratory, Migdal

11:40 – 12:00

High Throughput Chromatography with Monolithic HPLC Columns and Conventional HPLC Systems at Low Pressure
K. Cabrera

Merck KGaA, Darmstadt, Germany

Visualizing the Chemical Composition of Pharmaceuticals with Infrared Cameras
Stuart Wakefield
Malvern Instruments, UK

Analysis of Low Concentration of Perchlorate in Drinking Water and Ground Water by Ion Chromatography
Irena Pankratov
Israeli Water Commission, Bet Dagan

12:00 – 12:20

Fast Analysis and Increased Throughput in HPLC
John Cottam
Dionex (Europe) Management AG, Olten, Switzerland

Direct Visualisation and Analysis of Nanoparticles Using a New Laser-Based, Single Particle Tracking System
Jeremy Warren

NanoSight Ltd, Salisbury, UK

An Electroanalytical Method for Monitoring Toxic Metals in Sea Water
Michael Eldan
The Hebrew University, Jerusalem

12:20 – 14:00
Lunch, Posters & Vendor Exhibits
14:00 – 14:50

Chair: Eli Grushka
Mechanistic Aspects of Chiral Discrimination on Polysacharides Phases
Nelu Grinberg

Boehringer Ingelheim Phrmaceuticals Inc., Connecticut, USA

14:50 – 15:20
Coffee Break, Posters & Vendor Exhibits


Session D
15:20 – 16:20
Chair: Igal Bar Ilan

Session E

15:20 – 16:20
Chair: Danni Mandler

Session F

15:20 – 18:00
Chair: Raphy Bar

15:20 – 15:40

Pulsed Flow Modulation – A Novel Concept for Comprehensive GCxGC and GCxGC-MS with Supersonic Molecular Beams
Aviv Amirav
Tel-Aviv University,

Forensic Science and Nanotechnology: Applying Nanoparticles for Visualizing Latent Fingerprints
Matias Sametband
The Hebrew University, Jerusalem

Impurities Management in Pharmaceutical Analytical Chemistry: Unexpected Experiences
Bianca Avramovitch
Teva Pharmaceutical Industries LTD, Jerusalem

15:40 – 16:00

GC-MS Sensitivity – Approaching OFN Limits with Difficult Compounds
Alexander B. Fialkov
Tel-Aviv University,

The Differentiation Between the Controlled Substance Cathinone and its Geometrical Isomer 2-Methylamino-1-Phenylethanone
Dana Sonenfeld
Israel Police Headquarters, Jerusalem

Comparability and Compatibility of Proficiency Testing Results in Schemes with a Limited Number of Participants
Ilya Kuselman
National Physical Laboratory of Israel, Jerusalem

16:00 – 16:20

Novel Sample Handling Techniques in Gas Chromatography to Enhance Detection Limits and Improve Performance and Reliability
Massimo Santoro
PerkinElmer LAS, Monza, Italy

New Analytical Tools Onsite – Gas-Detector-Array (GDA2) for Monitoring
Hazardous Gases and Chemical Agents

Wolf Münchmyer
AIRSENSE Analytics GmbH, Schwerin, Germany

Process Capability of a Laboratory Test, a Tool for Completion of Validation and S.P.C
Eytan Sharon
Israel Laboratory Accreditation Authority, Ramat Gan

16:20 – 16:40
Coffee Break, Posters & Vendor Exhibits


Session G
16:40 – 17:40
Chair: Shula Levin

Session H
16:40 – 17:40
Chair: Valery Bulatov

Cont. of Session F

16:40 – 17:00

Discovery of Protein Biomarkers for Schizophrenia in Serum using Label-Free Relative Quantitation by LC-MS/MS
Yishai Levin
University of Cambridge, Cambridge, UK

Nanometric Chemical Sensing of Solution Ionic Concentrations Above Surfaces
Patricia Hamra
The Hebrew University, Jerusalem

Determination of Maximum Residue Levels (MRL) and Analytical Requirements
Stefan Soback
Kimron Veterinary Institute, Beit Dagan

17:00 – 17:20

The Maturity of Electron Ionization in LC-MS: an Efficient Approach for the Determination of Small Molecules and to Fight Signal Suppression and Other Matrix Effects
Achille Cappiello
University of Urbino, Urbino, Italy

Electrochemical Detection of Biological Reactions Using a Novel Nano-Bio-Chip Array
Judith Rishpon
Tel-Aviv University,

On Line Wet Chemistry Analysis of Fluids Using Classic Determination Method
Leopold Faschingleitner
Murtac Measurement and Control Systems, Analytic Chemistry Ltd.
Knittelfeld, Austria

17:20 – 17:40

Probing Protein Molecular Structure Utilising Ion Mobility Mass Spectrometry
Matt Kennedy
Waters, Manchester, UK

Small Molecule Analysis with Silicon NanoPowder-Assisted Laser Desorption/Ionization (SPALDI) Mass Spectrometry
Shai Dagan
University of Arizona, USA

Do Compliant Methods of Analysis of Waters and Wastes using ICP-AES and ICP-MS Meet QA/QC Requirements of ISO 17025 – What Are the Challenges and the Rewards?
Isaac (Joe) Brenner
National Cheng Kung University, Tainan, Taiwan

17:40 – 18:00

Novel Methods for Analysis of Drug Metabolites by LCMSMS
Ran Rosen
Agentek (1987) Ltd.,

Gold Island Film Transducers for Biological Sensing
Tatyana A. Bendikov
Weizmann Institute of Science, Rehovot


18:00 – 18:20
Determination of Chemical Residues in Foodstuffs by LC/MS/MS
Comparing QQQ and qTOF Mass Spectrometers.

David A. Weil
Agilent Technologies, Illinois, USA

Gated UV Raman Spectroscopy for Standoff Explosives Identification
Michael Gaft
LDS, Petach Tikva


January 24, 2007

07:30 - 09:00
09:00 – 09:10
Opening Remarks
09:10 – 10:00
Chair: Aviv Amirav
New Sources and Spectrometers for Chemical and Bioscience Analysis
Gary Hieftje

Indiana University, Indiana, USA
10:00 – 10:40
Coffee Break, Posters & Vendor Exhibits
Hall A
Hall B
Hall C


Session I
10:40 – 12:20
Chair: Ovadia Lev

Session J
10:40 – 12:20
Chair: Bianca Avramovitch


Session K

10:40 – 12:20
Chair: Shula Levin

10:40 – 11:00

Determination of Uranium Concentration in a Single Hair Strand by LAICPMS Applying Continuous and Single Pulse Ablation
Eyal Elish
Environmental Analytical Laboratories (EAL), Ben Gurion University of the Negev, Be'er Sheva

From the Manual Sampling of an Individual Dissolution Bath to the Fully Automated Double Bath Dissolution System for Solid Pharmaceutical Forms: Assembling and Validating the Automation of the Entire Dissolution Profile Measurements
Marta Lichtig
Taro Pharmaceutical Industries Ltd., Haifa

The Determination of Multiple Residues in Fruit and Vegetables Using 3200 Q TRAP LC/MS/MS
Paulina Goldshlag
Ministry of Agriculture and Rural Development,
Bet Degan

11:00 – 11:20

Matrix Induced Interferences Using Conventional and Enhanced Sample Introduction Systems for REE Determinations in Complex Water Samples Using High Resolution Magnetic Sector ICP-MS
Isaac (Joe) Brenner
National Cheng Kung University, Tainan, Taiwan

Increasing Role of Analytical Chemistry in the Design of Modern Pharmaceutical Solid State Dosage Forms
Berta Iosefzon-Kuyavskaya
Teva Pharmaceutical Industries, Jerusalem
Analysis of Drug Residues In Food by LC/MS
Malka Britzi
Kimron Veterinary
Institute, Beit Dagan
11:20 – 11:40

Pushing the Boundaries of ICP Performance with the iCAP 6000 Series - 66 Elements with Detection Limits Less than 1µg/L
Mathew Cassap
Thermo Electron, Cambridge, UK

Process Analytical Technology (PAT) in TEVA API Division, Using Near IR (NIR) for Quantitative Impurity Profile Instead of HPLC for Process Understanding
Ilana Nachum
API division TEVA, Netanya

Comparison of Sample Preparation Methods for Analysis of Melon Aroma by GC-MS
Irina Kuzmenkov
Frutarom Ltd, Haifa

11:40 – 12:00

ICP-MS for the Analysis of Clinical Samples
Alex Savin Saifan

Using Analytical Methods to Identify Polymorphism in Pharmaceutical Drug Substance
Amnon Pashusky
Taro R&D Institute, Haifa

Organophosphate Pesticides Hydrolysis in the Presence of Bifunctional Organoclay: Identification of the Intermidiate Responsable for the Catalysis
Ludmila Groisman
National Public Health Lab., Ministry of Health, Tel-Aviv

12:00 – 12:20

Analytical Method Development in Graphite Furnace Atomic Absorption Spectrometry
Martin Parker
Thermo Electron, Cambridge, UK

Fiber Optic Dissolution Testing: The Future is Here
Gilles Devidts
VARIAN S.A. Dissolution Products, Les Ulis France

Radical Induced Fragmentation of Amino Acid Esters Using Triphenc lcorrole(CuIII) Complexes

Chagit Denekamp
Technion - Israel Institute of Technology, Haifa

12:20 – 13:40
Lunch, Posters & Vendor Exhibits
13:40 – 14:00
14:00 – 14:50
Chair: Bianca Avramovitch
Proteomic Markers of Cancer Using
a Natural Glycoprotein Microarray Approach

David Lubman

University of Michigan, Michigan, USA  
14:50 – 15:20

Coffee Break, Posters & Vendor Exhibits



Session L

15:20 – 17:00
Chair: Judith Rishpon


Session M

15:20 – 17:00
Chair: Chagit Denekamp

15:20 – 17:00
Chair: Ilya Kuselman

15:20 – 15:40

The Proteome, the Degradome and the MHC Peptidome of Cancer and Autoimmunity
Arie Admon
Technion - Israel Institute of Technology, Haifa

Protecting Different Solid State Forms of Drugs
Michal Hackmey
Luzzatto & Luzzatto, Patent Attorneys, Jerusalem

Supramolecular in Analytical Chemistry
Yaduvendra Agrawal
Nirma University of Science & Technology, Ahmedabad, India

15:40 – 16:00

Use of NMR for Quantitative Determination of Complex Organic Mixtures
Amiram Groweiss
AG Consultants, Caesarea

Multi-Component Mycotoxin Analysis by LC/MS/MS
Thierry Faye
Varian, Inc., CA, USA

Minimum Weight - How Low Can You Go?
Gidi Wilenski
Agentek (1987) Ltd.,

16:00 – 16:20

Transformer Oil Analysis - A Method for the Prevention of Costly Failures in Power Transformers
Dr. Ehud Sutskover
Israel Electric Corp. Ltd., Haifa

Three Modes of Retention on the Same Stationary Phase: Separating Pharmaceutical Compounds Using Aqueous, Aqueous/Organic and Organic Eluents
Alexander Kovalerchik
Lab Experts

Critical Success Factors in Process Analyzers Technology
Gregory Shahnovsky
Modcon Systems Ltd, Haifa

16:40 – 17:00

Introducing Agilent OL, the Latest Innovation from Agilent Technologies for the Laboratory
Heiko Linde
Agilent Technologies,
Waldbronn, Germany

Prodrugs and Active Metabolites – Patent Protection and Infringement
Yigal Fraenkel
Reinhold Cohn and Partners, Tel-Aviv

Research Notebooks at your Fingertips
Rob Scoffin
CambridgeSoft, MA, USA


Awards: As in the past, The Israel Analytical Chemistry Society will recognize excellence for the
BEST POSTERS, with a 5000 NIS dedicated for these prizes


1 Determination of Trace Elements in Pigeon and Crow Feathers by ICPMS as Bioindicators for Environmental Pollution
A. Adout(1), D. Hawlena(2), R. Maman(1), O. Paz-Tal(1), Y. Hagag(1) and Z. Karpas(1)
1 - Nuclear Research Center, Negev, P. O. Box 9001, Be'er Sheva 84190
2 - Israel Nature and Parks Authority, Southern District, Be'er Sheva
2 A Novel Coumarin Bearing Calix[4]Arene Hydroxamic Acid for Liquid–Liquid Extraction, Separation, Preconcentration and Determination of Vanadium by Spectrophotometric and ICP- AES
Y. K. Agrawal and D. N. Thaker
Analytical Laboratory, Institute of Pharmacy, Nirma University of Science and Technology, Sarkhej-Gandhinagar Highway, Ahmedabad – 382 481, India
3 Extraction, Seperation and Preconcentration of Zirconium by Thiacalix-Crown Hydroxamic Acid
Y. K. Agrawal and J. P. Pancholi
Analytical Laboratory, Institute of Pharmacy, Nirma University of Science and Technology, Sarkhej-Gandhinagar Highway, Ahmedabad – 382 481, India

Experimental Conditions for the Scavenging of Palladium Complexes Using Functionalized Silicas
Frederic Chaumel(1), Francois Beland(1) and Alexander Kovalerchik(2)
1 - SiliCycle Inc.     
2 - Lab Experts, Israel

5 Aqueous Normal Phase Chromatography for LC/MS using Silica-Hydride Based Bonded Stationary Phases
Josef J. Pesek(1), Maria Matyska(1) and Alexander Kovalerchik(2)
1 - San Jose University Ca, USA, MicroSolv NJ, USA
2 - Lab Experts, Israel

Isotope Abundance Analysis for Improved Confidence Level in Sample Identification with the Supersonic GC-MS
Tal Alon, Alexander Gordin and Aviv Amirav
School of Chemistry, Tel-Aviv University, Tel-Aviv 69978

7 Pulsed Flow Modulation – A Novel Concept for Comprehensive GCxGC
Marina Poliak, Maya Kochman and Aviv Amirav
School of Chemistry, Tel-Aviv University, Tel-Aviv 69978
8 The Correlation between Chromatographic Behavior and Biopartioning Properties
Deborah Benhaim and Eli Grushka
Department of Inorganic and Analytical Chemistry, The Hebrew University, Jerusalem
9 Immobilized Liposomes Chromatography for the Determination of P artition Coefficient of Pharmacologically Related Compounds
Tali Godard, Chaim Gilon and Eli Grushka
Department of Inorganic and Analytical Chemistry, The Hebrew University, Jerusalem
10 HPLC ESI-LCMS Analysis Method for Determination of 8 Sudan AZO dyes using 1.8µm 5cm RP-18 Column
Igal Bar-Ilan and Gershon Melman

Department of Analytical Chemistry, MIGAL-Galilee Technologic Center, Kiryat-Shmona
11 Methane Conversion to Higher Hydrocarbons in Plasma
Tamas Kovacs(1), Tamas Turanyi(1) and Rowan T. Deam(2)
1 - Eotvos Lorand University (ELTE), Institute of Chemistry, H-1117 Budapest, Pazmany Peter setany 1/A, Hungary
2 - IRIS, Swinburne University Technology, 533-545 Burwood Road, P.O. BOX 218., 3122 Hawthorn, Victoria, Australia
12 Simultaneous Determination of Halide-Substituted Acid, Nitrile-Substituted Acid, Anhydride and their Corresponding Acid, by means of Normal-Phase Mode HPLC
Mark Vernik (1,2) and Eli Grushka(1)
1 - Department of Inorganic and Analytical Chemistry, The Hebrew University, Jerusalem
2 - AR&D Department, ChemAgis – A Subsidiary of Perrigo, Tel-Aviv
13 Automated Chromatographic Matching Application for the Analysis and Identification of Complex Mixtures
Dan Muller(1) and Zeev Amoyal(2)
1 - Arson Investigations, Division of Identification and Forensic Science, Israel Police National Headquarters, Jerusalem
2 - Bargal Analytical Instruments Ltd., Airport City
14 Development, Validation, and Application of a HPLC Stability Indicating Method of Liposome Encapsulated Antibiotics
Arthur Raskin(1), Inbar Elron-Gross(2), Ilana Schumacher(1) and Rimona Margalit(2)
1 - I.D.F Medical Corps, Military P.O. Box 02149, Israel.
2 - Department of Biochemistry, Tel-Aviv University, Tel-Aviv 69978
15 Development of a Reference Material for Obidoxime Chloride Determination
Ilana Schumacher(1), Paul Gornbein(1), Arthur Raskin(1) and Ilya Kuselman(2)
1 - Research & Quality Control Laboratory, Medical Corps, Israel Defense Forces, Israel
2 - National Physical Laboratory of Israel (INPL), Jerusalem
16 A Temperature Programmable Atmospheric Pressure Interface for LC/MS Analysis
John E. George, August Specht and Thierry Faye
Varian, Inc., Walnut Creek, California, USA
17 Determinationand Quantification of Cyanide Traces in Active Pharmaceutical Ingredients Using Modern Chromatograpgy Technologies
Lior Stern, Keren Weiss, Miri Adler, Svetlana Chechik and Arina Ceausu
Analytical R&D, Teva API division, Israel
18 Nitro-Phenyl-Carbamide Stationary Phases: CD-Screen Column for Analysis of Cyclodextrin Derivatives and p -Select Column for General-Purpose Applications
G. Varga(2), K. Csabai(1), L. Szente(1), I. Klebovich(3), K. Ludanyi(3)
and J. Szeman(1)
1 - CYCLOLAB Cyclodextrin Res. & Dev. Laboratory Ltd, Illatos u.7, Budapest, H-1097 Hungary
2 - ChiroQuest Chiral Technologies Development Ltd., Rumbach S. u. 7, Budapest, H-1075 Hungary
3 - Semmelweis University, Faculty of Pharmacy, Department of Pharmaceutics, Hץgyes Endre u. 7, Budapest, H-1092, Hungary
19 Determination of uranium in bioassays by ICP-MS and LA-ICP-MS (The saga of a family)
Hagit Sela(1,3), Zeev Karpas(1), Ofra Paz-Tal(1), Abraham Lorber(1), Yossi Hgag(1), Laina Salonen(2) Maarit Muikku(2) and J. Sabine Becker(3)
1 - Nuclear Research Center, Negev, P.O.Box 9001, Beer-Sheva 84190
2 - STUK—Radiation and Nuclear Safety Authority, Research and Environmental Surveillance, P.O.Box 14, FIN-00881 Helsinki, Finland
3 - Central Division of Analytical Chemistry Research Centre Juelich, D-52425 Juelich, Germany
20 Methodology of hair analysis by LA-ICP-SFMS
Hagit Sela(1,2), Zeev Karpas(1), Miroslav Zoriy(2), Carola Pickhardt(2)
and J. Sabine Becker(2)

1 - Nuclear Research Center, Negev, P.O.Box 9001, Be'er Sheva 84190
2 - Central Division of Analytical Chemistry Research Centre Juelich D-52425 Juelich, Germany
21 Dissolution Profile Measurements: Work Flow of the Fully Automated Unattended Double Bath Dissolution System for Extended Release Tablets
Amit Bronner and Marta Lichtig
Taro Pharmaceutical Industries Ltd., Haifa
22 Process Analytical Technology (PAT) - Near IR (NIR) Using Quantitative Impurity Profile analysis by NIR instead of HPLC for Process Understanding
Ilana Nachum, Galina Volter, Adi kleiman, Moshe Nulman, Ronen Sharf, Revital Rapoport and Amira Rottman
API division, ISRAEL BU, Plantex SITE, Netanya
23 Purification of Industrial Waste-Water from Heavy Metals by Precipitation and Flotation
Ilanit Treivish and Ze’ev Porat(1), Yoram Oren(2) and Avraham Marmur(3)
1 - Department of Analytical Chemistry, Nuclear research Center-Negev, P.O.Box 9001, Be’er-Sheva 84190
2 - Department of Environmental Engineering, Ben-Gurion Universiry, Be’er-Sheva 84105
3 - Department of Chemical Engineering, Technion-Israel Institute of Technology, Haifa
24 The Determination of Alkylphosphonic and Alkylphosphoric Acids by LC-MS/MS with Reverse Phase Chromatography at Acidic pH
Jacob Grunwald, Lilach Yishai Aviram, Liron Feldberg and Nitzan Tzanani
Department of Analytical Chemistry, Israel Institute For Biological Research (IIBR), Ness-Ziona 74100,
25 Retrospective Detection of Sarin in Ex-Vivo Blood Samples Compared with Human Blood Samples by Fluoride Reactivation Process and LVI-GC Detection
Merav Blanca, Miriam Herskovitz, Nitzan Tzanani, Jacob Grunwald and Ruth Barak
Analytical Chemistry Department, Israel Institute for Biological Research (IIBR), Ness-Ziona
26 Decomposition of Cyclic Triperoxides in ESI-MS
Alexander Tsoglin1,2 and Chagit Denekamp1
1 - Department of Chemistry and Institute of Catalysis Science and Technology, Technion - Israel Institute of Technology, Haifa
2 - Department M4, Rafael Ltd., Haifa

27 Development and Evaluation of an Inertial Probe for Mercury Speciation in Flue Gas with High Fly Ash Content
P.B.Stockwell1, W.T.Corns1 and T. Baldwin2 and J. Ward2
1 P.S. Analytical, Orpington, UK,, represented by Spectro Israel, Rishon Le-Zion,
2 Baldwin Environmental Inc, Reno, Nevada, USA

28 Screening and Analysis of electrical Instruments and Components
SPECTRO Analytical Instruments, Kleve, Germany,, represented by Spectro Israel, Rishon Le-Zion,
29 Instrumental Optimisation of Method 1631 to the Determination of Ultratrace Levels of Mercury in Water
D.W. Bryce, W.T.Corns & P.B.Stockwell
P.S. Analytical, Orpington, UK,, represented by Spectro Israel, Rishon Le-Zion,
30 Tris(2,4,6-Trimethoxyphenyl)Methyl Carbenium Ion for Charge Derivatization of Amines and Amino Acids
Emilia Rabkin1, Benoît Laleu2, Jérôme Lacour2 and Chagit Denekamp1
1 Department of Chemistry, Technion - Israel Institute of Technology, Haifa,
2 Department of Organic Chemistry, University of Geneva, Quai E. Ansermet 30, CH-1211 Geneva 4, Switzerland

31 Chiral Separation by Small Molecule Organogels
Shaul Mizrahi, Dan Rizkov and Ovadia Lev
The Casali Institute of Applied Chemistry, The Hebrew University of
Jerusalem, Jerusalem

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